NAD+

Primary Application: Cellular Energy, DNA Repair, and Mitochondrial Health

Fundamental Information

• Full Name: Nicotinamide Adenine Dinucleotide

• Chemical Formula: C21H27N7O14P2

• Role: Essential Metabolic Coenzyme

• Components: Nicotinamide ring, Adenine base, two sugar-phosphates

Detailed Overview

NAD+ is arguably the most important molecule for cellular health. While not a peptide, it is a “coenzyme” that exists in every single cell of your body. Its job is twofold: first, it acts like a shuttle, carrying electrons that allow your mitochondria (the cell’s powerhouses) to turn food into usable energy (ATP). Without NAD+, your cells would essentially run out of power and die within seconds.

Second, NAD+ acts as a signaling molecule that turns on “longevity genes” called sirtuins. These genes are responsible for fixing broken DNA, maintaining chromosomal health, and protecting the heart and brain from stress. As we age, our NAD+ levels naturally drop—often by as much as 50% by the time we hit middle age. This decline is linked to everything from muscle fatigue and weight gain to vision loss and cognitive decline. Research is heavily focused on restoring NAD+ levels to help “re-power” old cells and provide a healthy metabolic foundation that allows other rejuvenating treatments to work more effectively.

Scientific References Video

1. Verdin E. “NAD+ in aging, metabolism, and neurodegeneration.” Science. 2015;350(6265):1208-1213.

2. Amjad S, et al. “Role of NAD+ in regulating cellular and metabolic signaling pathways.” Mol Metab. 2021;49:101195.