CJC-1295 (With DAC)

Primary Application: Sustained Growth Hormone Elevation and Chronic Metabolic Research

Fundamental Information

• Alternative Name: DAC:GRF (Drug Affinity Complex: Growth Hormone-Releasing Factor)

• Amino Acid Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionyl)-NH2

• Molecular Formula: C165H271N47O46

• Molecular Weight: 3647.28 Daltons

• Half-Life: Approximately 6 to 8 days

Detailed Overview

CJC-1295 (with DAC) is a synthetic analog of the body’s natural Growth Hormone-Releasing Hormone (GHRH). It was specifically engineered to overcome the primary limitation of earlier growth-stimulating peptides: a very short lifespan in the body. The “DAC” stands for Drug Affinity Complex, a chemical addition that allows the peptide to bind permanently to albumin, the most common protein in human blood. This binding creates a “reservoir” effect, protecting the peptide from being broken down by enzymes and extending its activity from a few minutes to over a week.

Research indicates that a single administration can keep levels of Growth Hormone (GH) and Insulin-like Growth Factor-1 (IGF-1) significantly elevated for several days. In clinical studies, GH levels increased by 2-fold to 10-fold for at least 6 days post-injection, while IGF-1 levels remained elevated for up to two weeks. This sustained “plateau” of hormone release makes CJC-1295 DAC a primary subject for research into chronic growth hormone deficiency, fat metabolism (lipolysis), and the long-term repair of dense connective tissues. Because it does not require frequent dosing, it is often studied as a more convenient alternative to pulsatile peptides for general longevity and metabolic optimization.

Scientific References

1. Teichman SL, et al. “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.” Journal of Clinical Endocrinology and Metabolism. 2006.

   Ionescu M, Frohman LA. “Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.” Journal of Clinical Endocrinology and Metabolism. 2006.

2. Jette L, et al. “Human growth hormone-releasing factor (hGRF) 1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.” Endocrinology. 2005.